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Iowa State at Kansas odds, picks and prediction

Joe Williams
Sportsbook Wire

The Iowa State Cyclones (3-2, 3-1 Big 12) and Kansas Jayhawks (0-5, 0-4) meet at David Booth Kansas Memorial Stadium in Lawrence, Kan., for a noon ET kickoff Saturday (on FS1). Below, we analyze the Iowa State-Kansas college football betting odds and lines, with picks and predictions.

The Cyclones are No. 22 in the Amway Coaches Poll powered by USA TODAY Sports.

Iowa State at Kansas: Betting odds and lines

Odds via BetMGM; access USA TODAY Sports' betting odds for a full list. Lines last updated Tuesday at 11:35 p.m. ET.

  • Money line : Iowa State -3334 (bet $3,334 to win $100) | Kansas +1240 (bet $100 to win $1,240)
  • Against the spread/ATS : Iowa State -28.5 (-106) | Kansas +28.5 (-115)
  • Over/Under : 51.5 (O: -110 | U: -110)

Iowa State at Kansas: Three things to know

  1. The Cyclones are looking to bounce back after a narrow 24-21 setback at Oklahoma State last weekend, just missing a cover at +2.5. The Iowa State defense has been better of late, yielding just 19.5 PPG across the past two outings, both Under results.
  2. Things went from bad to worse for the winless Jayhawks last week. They were tuned up 55-14 by rivals Kansas State in Manhattan, Kan., last week, and they have now failed to cover in each of their five outings, too. The Jayhawks scoring defense ranks 98th, coughing up 45.0 PPG, so it's no surprise the Over is 4-0-1 in their five games.
  3. To make matters worse for Kansas, arguably its best player, RB Pooka Williams Jr., opted out of the season following a loss to West Virginia game on Oct. 17.

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Iowa State at Kansas: Odds, prediction, betting lines and picks

Prediction

Iowa State 41, Kansas 10

Money line (ML)

PASS. It's hard to envision a scenario where Kansas tops Iowa State, but laying more than 33 times your potential return is just silly, even if you were to toss I-State into a 10-team parlay. It's just not worth the risk.

Against the spread (ATS)

IOWA STATE ( -28.5, -106) is the play here, as it's just hard to put good money on lowly Kansas (+28.5, -115). The book tries to tempt you with that hook on a 28, but it's just not worth it. KU is bad, and showing no signs of turning things around. Even the great Les Miles can't fix this mess.

Over/Under (O/U)

UNDER 51.5 ( -110) is the play, although the giving defense of the Jayhawks will make you sweat all night. Iowa State's pass attack has the potential to take care of this Over all by itself if it's clicking early. Still, Kansas won't give you much to sweat about, and eventually the 'Clones will call off the dogs once it gets out of hand.

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